Paris Brain Institute soon to celebrate 15 years of research on brain disorders and salutes the support of the Edmond J. Safra Foundation
Based at the Pitié-Salpêtrière hospital in Paris, the largest neurological hospital in France, the Institut du Cerveau, or Paris Brain Institute, will soon celebrate 15 years of leading brain research.
The Institute’s President, Gérard Saillant, declared: “On the cusp of its fifteenth anniversary, Paris Brain Institute’s ambition is clear: to continue its progress as one of the world’s leading neuroscience research institutes, committed to advancing the fight against brain disorders. We would not be in this position today without the faith and support of the Edmond J Safra Philanthropic Foundation.”
Here are some of its latest contributions to brain science:
- Alzheimer’s disease could be considered as a neurodevelopmental disorder
Subtle disruptions associated with the Amyloid-beta precursor protein during the development of the brain in the womb could be associated with the onset of Alzheimer’s disease much later in life.
Read Bassem Hassan’s team findings - Sleep could be a gateway to creativity
The transition between wakefulness and sleep offers a gateway to creativity. By identifying sleep onset as a key period for inspiring insight, this study provides a well-identified window on which to focus when investigating the neural mechanisms of creative problem-solving.
Read the full article published by Célia Lacaux in the scientific review Science - Role of senescent cells in brain tumor
Researchers at Paris Brain Institute examined the role of senescent cells, i.e. cells that have stopped dividing, in the progression of glioblastoma, the most common brain tumor in adults. Molecules targeting and killing senescent cells had the effect of modifying the tumor ecosystem and slowing its progression, opening a new therapeutic way to increase the effectiveness of conventional treatments.
Read the full article in the scientific review Nature Communications - New mapping of neurons involved in locomotion
Recent work by the Sensory Spinal Signaling technique has shown that walking is controlled by a brain region known as the mesencephalic locomotor region, which controls the vigor and speed of movement and transmits the nerve messages to the spinal cord via control neurons located in the brain stem. This new mapping, carried out in zebrafish, could contribute to our understanding of the movement control circuits that are deficient in Parkinson’s disease.
Read the full study in scientific review Nature - Predicting stroke outcomes with MRI in the acute phase
A machine-learning model based on MRI results can now be acquired on day one following a stroke. These results could point the way to patient categorization strategies for neuroprotective and rehabilitative therapies that optimize patient recovery.
Read more about this technique
For further details, read Paris Brain Institute’s full Annual Report for 2023.
